Exploring new indications for statins beyond atherosclerosis: Successes and setbacks

New Drugs for Treating Dyslipidemia: Beyond Statins

Statins have been shown to be very effective and safe in numerous randomized clinical trials, and became the implacable first-line treatment against atherogenic dyslipidemia. However, even with optimal statin treatment, 60% to 80% of residual cardiovascular risk still exists. The patients with familial hypercholesterolemia which results in extremely high level of low density lipoprotein cholest...

Antioxidants, statins, and atherosclerosis.

Research into the oxidation of lipoproteins has yielded many new insights into the pathogenesis of atherosclerosis. However, despite lipoprotein oxidation's biologically plausible role in atherogenesis, several studies have reported inconsistent effects of antioxidants on clinical coronary end points, in sharp contrast with the studies of lipid modification with the 3-hydroxy-3-methylglutaryl c...

Biomedical methods for HIV prevention: new setbacks.

In terms of prevention, I will focus on 4 main issues. First, there is the problem of identifying those recently infected with HIV. Annual HIV transmission rates in the United States are 3.5-fold higher among persons with undiagnosed infection as among those who know they are infected.1 Groups classically identified as low risk for HIV infection, such as married heterosexual men with children, ...

Atherosclerosis: Successes, Surprises, and Future Challenges.

Beyond Pixels: Exploring New Representations and Applications for Motion Analysis

The focus of motion analysis has been on estimating a flow vector for every pixel by matching intensities. In my thesis, I will explore motion representations beyond the pixel level and new applications to which these representations lead. I first focus on analyzing motion from video sequences. Traditional motion analysis suffers from the inappropriate modeling of the grouping relationship of p...